·From: The South on I-95. Take Exit 8. Make a right on Highway 278, five miles, left on Argent Road eight miles, left onto Highway 170; follow into Beaufort. Merge right Highway 21 South 2.2 miles down Highway 21. Keep straight onto business Route 21. Next traffic light turn right on to Bladen Street. Follow Bladen Street for seven blocks, make a left onto Bay Street. Follow Bay five blocks, the Best Western Sea Island Inn is on the left side across from the marina. ·From: The North on I-95. Take Exit 38 from Interstate 95. Turn right off the exit ramp onto Highway 68. Highway 68 will turn into Highway 17/US 21 South. Follow US Highway 21 South all the way into Beaufort. When you reach town keep straight onto Business Route 21. Next traffic light turn right on to Bladen Street. Follow Bladen Street for seven blocks, make a left onto Bay Street. Follow Bay five blocks, the Best Western Sea Island Inn is on the left side across from the marina. ·From: The West on US 278/SC363. US Highway 278/SC 363 turns into Highway 68 and then turns into Highway 17/US Highway 21. Follow US Highway 21 south all the way into Beaufort. When you reach town keep straight onto Business Route 21. Next traffic light turn right on to Bladen Street. Follow Bladen Street for seven blocks, make a left onto Bay Street. Follow Bay five blocks, the Best Western Sea Island Inn is on the left side across from the marina.