�From: Galesburg - Interstate 74 Take Exit 34 West to 67 South to Macomb, 1655 East Jackson Street (Highway 67 and 136) to the Best Western Macomb Inn. �From: Chicago - Interstate 55. Take Exit 80 West to Interstate 74 East (Galesburg) to 34 West to 67 South to Macomb, 1655 East Jackson Street (Highway 67 and 136) to the Best Western Macomb Inn. �From: St Louis, MO - Interstate Take Exit Interstate 72 West (Springfield) to Route 4 North to 97 West to 125 West to 67 North to Macomb, 1655 East Jackson Street (Highway 67 and 136) to the Best Western Macomb Inn. �From: Quincy - Interstate 172. From 336 North to 136 East to Macomb, 1655 East Jackson Street (Highway 136 and 67) to the Best Western Macomb Inn.